TRAIL Death Receptor-4, Decoy Receptor-1 and Decoy Receptor-2 Expression on CD8(+) T Cells Correlate with the Disease Severity in Patients with Rheumatoid Arthritis

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BISGIN A., TERZIOGLU E., AYDIN C., Yoldas B., YAZISIZ V., BALCI N., ...More

BMC MUSCULOSKELETAL DISORDERS, vol.11, 2010 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 11
• Publication Date: 2010
• Doi Number: 10.1186/1471-2474-11-192
• Journal Name: BMC MUSCULOSKELETAL DISORDERS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Akdeniz University Affiliated: Yes

Abstract

Background: Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disorder. Although the pathogenesis of disease is unclear, it is well known that T cells play a major role in both development and perpetuation of RA through activating macrophages and B cells. Since the lack of TNF-Related Apoptosis Inducing Ligand (TRAIL) expression resulted in defective thymocyte apoptosis leading to an autoimmune disease, we explored evidence for alterations in TRAIL/TRAIL receptor expression on peripheral T lymphocytes in the molecular mechanism of RA development.