Antimicrobial activities of essential oils on microorganisms isolated from radiation dermatitis

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KOCA T., KOCA O., Korcum A. F.

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, cilt.10, sa.3, ss.307-310, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4328/jcam.6132
  • Dergi Adı: JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), EMBASE
  • Sayfa Sayıları: ss.307-310
  • Anahtar Kelimeler: Radiation Dermatitis, Essential Oils, Antimicrobial Activity, PREVENTION, SKIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study was to investigate the antimicrobial effect of essential oils obtained from Mediterranean region plants on microorganisms isolated as secondary skin infections in patients with Grade II and Ill acute radiation dermatitis. Material and Method: The antimicrobial activity of essential oils, Origanum vulgare (O. vulgare), Lavandula intermedia (L intermedia) and Thymus vulgaris (T. vulgaris) were evaluated by broth microdilution method on microorganisms isolated from 20 patients with Grade II and III radiation dermatitis. Microdilutions had modified according to The Clinical and Laboratory Standards Institute (CLSI) recommendations and lowest concentration which inhibited growth after incubation was identified as Minimal Inhibitory Concentration (MIC). The severity degree of acute radiation dermatitis was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03. Results: Nine pathogenic strains were isolated from 20 samples of the patients. The pathogens isolated from skin swabs of the patients with Grade II and III radiation dermatitis were Methicillin-resistant Staphylococcus aureus (MRSA), rnethicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant coagulase-negative Staphylococcus (MRCNS), methicillin-sensitive coagulase-negative Staphylococcus (MSCNS), Klebsiella pneumoniae (K. pneumoniae) and Candida albicans (C. albicans). Minimal Inhibitory Concentration values of O. vulgare, L intermedia and T. vulgaris for each isolated microorganisms were found. These essential oils have been found effective on microorganisms isolated from secondary infections of radiation-related dermatitis. Discussion: Antimicrobial activity of O. vulgare, L intermedia and T. vulgaris essential oils on pathogenic microorganisms isolated from radiation dermatitis were determined. Future use of essential oils in the treatment of acute radiation dermatitis should be considered.