Anandamide initiates Ca2+ signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells

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ZORATTI C., KIPMEN-KORGUN D., OSIBOW K., MALLI R., Graier W.

BRITISH JOURNAL OF PHARMACOLOGY, cilt.140, sa.8, ss.1351-1362, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 140 Sayı: 8
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1038/sj.bjp.0705529
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1351-1362
  • Anahtar Kelimeler: cameleon, CB2 receptor, Ca2+ mobilization, endoplasmic reticulum Ca2+, mitochondrial Ca2+, phospholipase C, ratiometric-pericam-mt, SR141716A, SR144528, GREEN FLUORESCENT PROTEINS, CANNABINOID RECEPTORS, MESENTERIC VASODILATION, SELECTIVE ANTAGONIST, CORONARY-ARTERY, RELAXATION, MECHANISMS, EXPRESSION, BRADYKININ, RESPONSES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

1 The endocannabinoid anandamide has been reported to affect neuronal cells, immune cells and smooth muscle cells via either CBI or CB2 receptors. In endothelial cells, the receptors involved in activating signal transduction are still unclear, despite the fact that anandamide is produced in this cell type.