Anandamide initiates Ca2+ signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells

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ZORATTI C., KIPMEN-KORGUN D., OSIBOW K., MALLI R., Graier W.

BRITISH JOURNAL OF PHARMACOLOGY, vol.140, no.8, pp.1351-1362, 2003 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 140 Issue: 8
  • Publication Date: 2003
  • Doi Number: 10.1038/sj.bjp.0705529
  • Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1351-1362
  • Keywords: cameleon, CB2 receptor, Ca2+ mobilization, endoplasmic reticulum Ca2+, mitochondrial Ca2+, phospholipase C, ratiometric-pericam-mt, SR141716A, SR144528, GREEN FLUORESCENT PROTEINS, CANNABINOID RECEPTORS, MESENTERIC VASODILATION, SELECTIVE ANTAGONIST, CORONARY-ARTERY, RELAXATION, MECHANISMS, EXPRESSION, BRADYKININ, RESPONSES
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

1 The endocannabinoid anandamide has been reported to affect neuronal cells, immune cells and smooth muscle cells via either CBI or CB2 receptors. In endothelial cells, the receptors involved in activating signal transduction are still unclear, despite the fact that anandamide is produced in this cell type.