Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

Erbas-Cakmak, Sundus; Cakmak, Fatma; Topel, Seda; Uyar, Taha; AKKAYA, Engin

doi:10.1039/c5cc01261a

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

Erbas-Cakmak S., Cakmak F. P., Topel S. D., Uyar T. B., AKKAYA E. U.

CHEMICAL COMMUNICATIONS, vol.51, no.61, pp.12258-12261, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 51 Issue: 61
Publication Date: 2015
Doi Number: 10.1039/c5cc01261a
Journal Name: CHEMICAL COMMUNICATIONS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.12258-12261
Open Archive Collection: AVESIS Open Access Collection
Akdeniz University Affiliated: Yes

Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pK(a) values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.