Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

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Erbas-Cakmak S., Cakmak F. P., Topel S. D., Uyar T. B., AKKAYA E. U.

CHEMICAL COMMUNICATIONS, cilt.51, sa.61, ss.12258-12261, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 61
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1039/c5cc01261a
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.12258-12261
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Akdeniz Üniversitesi Adresli: Evet

Özet

A series of pH and GSH responsive photosensitizers were designed and synthesized. pK(a) values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.