Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers
CHEMICAL COMMUNICATIONS, cilt.51, sa.61, ss.12258-12261, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 61
- Basım Tarihi: 2015
- Doi Numarası: 10.1039/c5cc01261a
- Dergi Adı: CHEMICAL COMMUNICATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.12258-12261
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Akdeniz Üniversitesi Adresli: Evet
Özet
A series of pH and GSH responsive photosensitizers were designed and synthesized. pK(a) values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.