Comparing Various Surgical Delay Methods with Ischemic Preconditioning in the Rat TRAM Flap Model
JOURNAL OF RECONSTRUCTIVE MICROSURGERY, cilt.30, sa.5, ss.335-341, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 5
- Basım Tarihi: 2014
- Doi Numarası: 10.1055/s-0033-1363326
- Dergi Adı: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.335-341
- Anahtar Kelimeler: ischemic preconditioning, surgical delay, TRAM flap, SKELETAL-MUSCLE, BLOOD-FLOW, BREAST RECONSTRUCTION, SKIN FLAPS, SURVIVAL, ABDOMINOPLASTY, AUGMENTATION, EXPERIENCE, INFARCTION, PIG
- Akdeniz Üniversitesi Adresli: Evet
Özet
Both surgical delay and ischemic preconditioning (IP) have been shown to be effective in improving the survival Of flaps. We used a variety of flap delay methods and IP to increase the surviving area of the transverse rectus abdominis musculotutaneous (TRAM) flap in rats, and the results are compared in between. A 6- x 3-cm sized TRAM flap in 40 Wistar rats Was allocated into five groups. Group 1: TRAM flap was elevated from nondominant pedicle, and the flap was sutured to the original bed. Group 2: Left superior deep epigastric vessels (SDEV) were cut; 1 week later, TRAM flap was elevated. Group 3: Only skin incision Was done; 1 week later, TRAM flap was elevated. Group 4: Skin incision was done, and the left SDEV were Cut; 1 week later, TRAM flap was elevated. Group 5: TRAM flap was elevated; IP was performed using three cycles of 10 minutes of repeated ischemia/reperfusion (I/R) periods, and the flap was sutured, to the original bed. The surviving area of the:flap was statistically significant between the control and groups 2, 4, and 5 (p < 0.001), and groups 4 and 2 were superior to group 5. Although preconditioning has been intensively studied for the last two decades and partly provided its beneficial effects in I/R injury, we determined the IP increased the surviving area of the TRAM flap but not effective as much as surgical delay method.