Akademik Veri Yönetim Sistemi
UROLOGIA INTERNATIONALIS, 2023 (SCI-Expanded)
Introduction: The purpose of our study was to evaluate reliability of 68Ga-labeled prostate spesific membrane antigen positron emission tomography (Ga-68-PSMA PET/CT) and identify appropriate SUVmax cut-off values in order to use for diagnosis especially in patients remained clinically suspicious for prostate cancer (PCa).Methods: Eighty-four patients applied( 68)Ga-PSMA PET/CT subsequent to transrectal ultrasound guided prostate biopsy (TRUS-bx) involved in this study retrospectively. Ga-68-PSMA PET/CT imagings were anaylzed by a nuclear medicine physician and Region of interests (ROI) were drawn manually in prostate diagrams including 6 segments for each patient. These marked diagrams were analyzed with histopathology reports TRUS-bx. 504 segments were grouped with Gleason scoring system and all groups were compared with mean SUV(max )values.Results: Mean SUV(max )value of Gleason grade group 1 (GG1, n:352 segments) was 6.6 (+/- 4.6) and significantly lower than the other groups (p<0.001). No significant difference was detected within GG2-5 groups (p>0.05). According to ROC curve analysis, SUVmax cut-off values were 1.0 (AUC:0.961) for tumor detection, yielding a sensitivity, specifity, PPV, NPV 99.4%, 92.1%, 96.5%, 98% and 4.2 (AUC:0.853) for detection clinically significant prostate cancer with 88.8%, 62.4%, 84.5% and 71% respectively. Although tumor percentage of biopsy core and Gleason group were correlated with SUVmax uptake, but patient age was not. Conclusion: Ga-68-PSMA PET appears to be a reliable option for diagnosis and disease management in PCa, can be considered especially in discrimination of csPCa and patients remained suspicious for disease.