Magic ferritin: A novel chemotherapeutic encapsulation bullet

Simsek E., Kilic M. A.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol.293, no.1, pp.509-513, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 293 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jmmm.2005.01.066
  • Journal Name: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.509-513
  • Keywords: apoferritin, doxorubicin, encapsulation, ferritin, chemotherapy, DRUG-DELIVERY, LIPOSOMES, RECEPTOR, SERUM
  • Akdeniz University Affiliated: Yes

Abstract

The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin-HCl gives rise to a solution containing five doxorubicin-HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity. (c) 2005 Published by Elsevier B.V.