Monte Carlo simulation for statistical mechanics model of ion-channel cooperativity in cell membranes
PHYSICAL REVIEW E, cilt.79, sa.3, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 79 Sayı: 3
- Basım Tarihi: 2009
- Doi Numarası: 10.1103/physreve.79.031919
- Dergi Adı: PHYSICAL REVIEW E
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: bioelectric phenomena, biomembranes, cellular biophysics, molecular biophysics, Monte Carlo methods, proteins, statistical mechanics, COLLECTIVE BEHAVIOR, GATING KINETICS, ELECTRIC-FIELDS, RECEPTORS, DYNAMICS, VOLTAGE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Akdeniz Üniversitesi Adresli: Hayır
Özet
Voltage-gated ion channels are key molecules for the generation and propagation of electrical signals in excitable cell membranes. The voltage-dependent switching of these channels between conducting and nonconducting states is a major factor in controlling the transmembrane voltage. In this study, a statistical mechanics model of these molecules has been discussed on the basis of a two-dimensional spin model. A new Hamiltonian and a new Monte Carlo simulation algorithm are introduced to simulate such a model. It was shown that the results well match the experimental data obtained from batrachotoxin-modified sodium channels in the squid giant axon using the cut-open axon technique.