Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke
NEUROLOGICAL RESEARCH, cilt.40, sa.5, ss.364-371, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 5
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/01616412.2018.1446281
- Dergi Adı: NEUROLOGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.364-371
- Anahtar Kelimeler: CYP24A1, CYP2R1, single nucleotide polymorphism, vitamin D, ischemic stroke, 25-HYDROXYVITAMIN D, CARDIOVASCULAR-DISEASE, DENDRITIC CELLS, D DEFICIENCY, 1,25-DIHYDROXYVITAMIN D-3, ENDOTHELIAL DYSFUNCTION, CYP27B1 POLYMORPHISMS, ASSOCIATION, SUSCEPTIBILITY, RATS
- Akdeniz Üniversitesi Adresli: Evet
Özet
Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.