Atıf İçin Kopyala
ÖZÇELİK A., Oner T., CAN DEMİRDÖĞEN B., Bek V. S., Demirkaya S., ADALI O.
NEUROLOGICAL RESEARCH, cilt.40, sa.5, ss.364-371, 2018 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
40
Sayı:
5
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Basım Tarihi:
2018
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Doi Numarası:
10.1080/01616412.2018.1446281
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Dergi Adı:
NEUROLOGICAL RESEARCH
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.364-371
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Anahtar Kelimeler:
CYP24A1, CYP2R1, single nucleotide polymorphism, vitamin D, ischemic stroke, 25-HYDROXYVITAMIN D, CARDIOVASCULAR-DISEASE, DENDRITIC CELLS, D DEFICIENCY, 1,25-DIHYDROXYVITAMIN D-3, ENDOTHELIAL DYSFUNCTION, CYP27B1 POLYMORPHISMS, ASSOCIATION, SUSCEPTIBILITY, RATS
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Akdeniz Üniversitesi Adresli:
Evet
Özet
Objective: Vitamin D deficiency is known as an important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Genetic variations including single nucleotide polymorphisms (SNPs) in enzymes involved in vitamin D metabolism can affect susceptibility to the development of stroke. Therefore, the objective of this study was to investigate the association between polymorphisms of vitamin D metabolizing enzymes (rs927650 SNP in CYP24A1, and rs10741657 SNP in CYP2R1 genes,) and ischemic stroke risk in Turkish population.