The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions

Sadullahoglu C., NART D., VERAL A.

DIAGNOSTIC CYTOPATHOLOGY, cilt.45, sa.2, ss.118-124, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/dc.23653
  • Dergi Adı: DIAGNOSTIC CYTOPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.118-124
  • Anahtar Kelimeler: malignant effusion, MOC-31, EZH2, reactive mesothelial cell, REACTIVE MESOTHELIAL CELLS, IMMUNOCYTOCHEMICAL PANEL, ADENOCARCINOMA, CARCINOMA, MARKER, IMMUNOHISTOCHEMISTRY, COEXPRESSION, CALRETININ, ACCURACY, CYTOLOGY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

BackgroundAll malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due to injury of serosal surfaces from mesothelioma or malignant epithelial tumor cells. Epithelial and mesothelial immunohistochemical markers can be used in such conditions. The aim of this study was to evaluate the expression of two immunohistochemical markers (MOC-31 and EZH2) in serosal effusions.