COMPARISON OF THE EFFICACY AND SAFETY OF DIRECT-ACTING ANTIVIRAL AGENTS IN THE TREATMENT OF HEPATITIS C VIRUS GENOTYPE 1 BETWEEN THE TURKISH ELDERLY AND YOUNGER POPULATION

Creative Commons License

ADANIR H., AKIN M., Alkan E.

TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, cilt.25, sa.1, ss.68-78, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.31086/tjgeri.2022.264
  • Dergi Adı: TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.68-78
  • Anahtar Kelimeler: Geriatrics, Hepatitis C, Chronic, Therapy, SOFOSBUVIR PLUS RIBAVIRIN, CLINICAL-OUTCOMES, REAL-WORLD, THERAPY, INFECTION, CIRRHOSIS, COHORT, RISK
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Direct-acting antiviral agents are highly effective and safe treatments for chronic hepatitis C infection; however, the treatment may be more problematic in elderly patients due to accompanying comorbid conditions. This study aimed to assess the efficacy and safety of direct-acting antiviral agents among the hepatitis C virus genotype 1 infected Turkish elderly population ( 65 years) and 48 (50%) constituted Group 2 ( _65 years). Comorbidities, potential drug-drug interactions, the number of interacting drugs, adverse events, and sustained virologic response rates were evaluated and compared between the groups. Results: Sustained virologic response rates were 100% for both of the groups, except for the two patients with substance abuse in Group 1 who dropped from the study. Patients in Group 2 had more cirrhosis (p = 0.005) and respiratory diseases (p = 0.037). There was no significant difference between the two groups in terms of side effects (p = 0.683); however, side effects were significantly higher in the elderly group with two or more potential drug interactions (p = 0.049). The presence of cardiovascular disease was also found to be associated with more side effects in the elderly (p = 0.022). Conclusion: Direct-acting antiviral regimens are highly effective in elderly patients without a significant increase in the risk of side effects.