The Anti-angiogenic and Anti-microbial Effect of Diosmin: Potential Receptor Interactions via Molecular Docking

ŞİMŞEK E., Koçak O., YILDIRIM K., Kuruoğlu A., Taşkın N. D., Bozkurt S., ...Daha Fazla

Revista Brasileira de Farmacognosia, cilt.33, sa.2, ss.422-431, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s43450-023-00365-y
  • Dergi Adı: Revista Brasileira de Farmacognosia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.422-431
  • Anahtar Kelimeler: Binding modes, Flavonoid, VEGF-VEGFR, Hormone receptors, OmpA, Molecular modeling
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This study examined the antiangiogenic capacity of diosmin in vitro and their interactions with certain important receptors related to cancer and infectious diseases via molecular docking. Diosmin, a naturally occurring flavone glycoside, largely found in citrus fruits, exhibits potentially antiangiogenic properties especially interacting with both VEGF and VEGFR. Treatment with certain doses of diosmin caused a reduction with a ratio of 22–68% on VEGF levels as compared to non-treated control groups. Western blotting and real-time PCR results demonstrated that protein expression of VEGF was downregulated in a dose- and time-dependent manner. On the other hand, we aimed to check the possible interaction of diosmin with VEGF, VEGFR, HER, PR, ER, and Omp-a, receptor proteins. According to our molecular docking results, diosmin effectively binds these receptors and probably this could be one of the possible reasons for its anti-angiogenic and anti-microbial properties. Graphical Abstract: [Figure not available: see fulltext.].