Tolerance to rat heart grafts induced by intrathymic immunomodulation is mediated by indirect recognition primed CD4+ CD25(+) T-reg cells
TRANSPLANTATION, vol.79, no.11, pp.1492-1497, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 79 Issue: 11
- Publication Date: 2005
- Doi Number: 10.1097/01.tp.0000159870.01567.02
- Journal Name: TRANSPLANTATION
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1492-1497
- Keywords: CD4(+)CD25(+) T-reg cells, chronic rejection, tolerance, intrathymic immunomodulation, indirect recognition, IMMUNOLOGICAL SELF-TOLERANCE, CLASS-I ALLOPEPTIDES, CARDIAC ALLOGRAFTS, TRANSPLANTATION TOLERANCE, IMMUNOREGULATORY CELLS, CUTTING EDGE, REJECTION, INDUCTION, PEPTIDE, VIVO
- Akdeniz University Affiliated: No
Abstract
Background. In a rat model (PVG.R8-to-PVG.1U) disparate for one class I antigen, RT.1A(a), we previously demonstrated that intrathymic immunomodulation with donor antigens resulted in prolonged survival of cardiac allografts that underwent chronic rejection. However, long-term survivors developed a regulatory cell population that prevented both acute and chronic rejection when adoptively transferred into secondary graft recipients. The purpose of this study wag to characterize these regulatory cells with particular emphasis on CD4(+)CD25(+) T-reg cells.