Tolerance to rat heart grafts induced by intrathymic immunomodulation is mediated by indirect recognition primed CD4+ CD25(+) T-reg cells

Koksoy S., ELPEK K., YOLCU E., SHIRWAN H.

TRANSPLANTATION, cilt.79, sa.11, ss.1492-1497, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 11
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1097/01.tp.0000159870.01567.02
  • Dergi Adı: TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1492-1497
  • Anahtar Kelimeler: CD4(+)CD25(+) T-reg cells, chronic rejection, tolerance, intrathymic immunomodulation, indirect recognition, IMMUNOLOGICAL SELF-TOLERANCE, CLASS-I ALLOPEPTIDES, CARDIAC ALLOGRAFTS, TRANSPLANTATION TOLERANCE, IMMUNOREGULATORY CELLS, CUTTING EDGE, REJECTION, INDUCTION, PEPTIDE, VIVO
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Background. In a rat model (PVG.R8-to-PVG.1U) disparate for one class I antigen, RT.1A(a), we previously demonstrated that intrathymic immunomodulation with donor antigens resulted in prolonged survival of cardiac allografts that underwent chronic rejection. However, long-term survivors developed a regulatory cell population that prevented both acute and chronic rejection when adoptively transferred into secondary graft recipients. The purpose of this study wag to characterize these regulatory cells with particular emphasis on CD4(+)CD25(+) T-reg cells.