Chronic Granulomatous Disease

Filiz S., Kocacık Uygun D. F., Yeğin O.

Turkish Journal of Immunology, vol.1, no.1, pp.22-31, 2013 (Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 1 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.hoc.2012.11.002
  • Journal Name: Turkish Journal of Immunology
  • Journal Indexes: Scopus
  • Page Numbers: pp.22-31
  • Keywords: Chronic granulomatous disease, Gene defects, NADPH oxidase, Immune defect, Inflammatory bowel disease, DISCOID LUPUS-ERYTHEMATOSUS, INTERFERON-GAMMA THERAPY, INVASIVE ASPERGILLOSIS, CLINICAL-FEATURES, INCREASED SUSCEPTIBILITY, NADPH OXIDASE, GENE-THERAPY, IN-VIVO, INFECTIONS, CGD
  • Akdeniz University Affiliated: Yes

Abstract

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation for nonmalignant diseases. Therefore, CGD is worthy of attention for its historical interest and because it is a disease for which expert management is imperative.