Serum ghrelin concentrations are increased in children with growth hormone insensitivity and decrease during long-term insulinlike growth factor-I treatment

Uckun-Kitapci A., Haqq A. M., PURNELL J. Q., NEWCOMB K., Gulkesen H., Underwood L. E.

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.56, sa.1, ss.26-31, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2310/jim.0b013e3181620425
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.26-31
  • Anahtar Kelimeler: ghrelin, IGF-I, GHIS, LARON-SYNDROME, BODY-COMPOSITION, STATURAL GROWTH, DEFICIENCY, RESISTANCE, ADULTS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Ghrelin increases food intake, body weight, and growth hormone (GH) secretion. Serum concentrations of ghrelin are low in obese hyperinsulinemic persons, are reduced by infusion of insulin into normal-weight subjects, and are increased in underweight hypoinsulinemic patients with anorexia nervosa. Laron syndrome is an autosomal recessive disorder of GH insensitivity that results in decreased insulinlike growth factor-I (IGF-I) synthesis and growth failure. These patients have elevated GH levels, excess adipose tissue , and are insulin resistant. Because IGF-I has insulinlike actions and patients with GH insensitivity syndrome (GHIS) exhibit excess adiposity, we sought to determine whether ghrelin levels were elevated in these patients and potentially regulated by IGF-I replacement.