Serum ghrelin concentrations are increased in children with growth hormone insensitivity and decrease during long-term insulinlike growth factor-I treatment
JOURNAL OF INVESTIGATIVE MEDICINE, cilt.56, sa.1, ss.26-31, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.2310/jim.0b013e3181620425
- Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.26-31
- Anahtar Kelimeler: ghrelin, IGF-I, GHIS, LARON-SYNDROME, BODY-COMPOSITION, STATURAL GROWTH, DEFICIENCY, RESISTANCE, ADULTS
- Akdeniz Üniversitesi Adresli: Evet
Özet
Background: Ghrelin increases food intake, body weight, and growth hormone (GH) secretion. Serum concentrations of ghrelin are low in obese hyperinsulinemic persons, are reduced by infusion of insulin into normal-weight subjects, and are increased in underweight hypoinsulinemic patients with anorexia nervosa. Laron syndrome is an autosomal recessive disorder of GH insensitivity that results in decreased insulinlike growth factor-I (IGF-I) synthesis and growth failure. These patients have elevated GH levels, excess adipose tissue , and are insulin resistant. Because IGF-I has insulinlike actions and patients with GH insensitivity syndrome (GHIS) exhibit excess adiposity, we sought to determine whether ghrelin levels were elevated in these patients and potentially regulated by IGF-I replacement.