The Correlation between IL-1 beta-C31T Gene Polymorphism and Susceptibility to Breast Cancer

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ERAS N., Datoglu F. T., ÇOLAK T., Guler M., AKBAŞ E.

JOURNAL OF BREAST CANCER, vol.22, no.2, pp.210-218, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.4048/jbc.2019.22.e27
  • Journal Name: JOURNAL OF BREAST CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.210-218
  • Keywords: Breast neoplasms, Genetic susceptibility, Interleukin-1beta, Polymorphism, genetic, INTERLEUKIN-1-BETA GENE, INCREASED RISK, IL-1B, ASSOCIATION, EXPRESSION, CYTOKINES, C/T
  • Akdeniz University Affiliated: Yes

Abstract

Purpose: Interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine, has been shown to influence breast cancer susceptibility. The relationship between its risk of breast cancer and IL-1 beta-C31T polymorphism has been demonstrated, but the results remain controversial. Therefore, our study aimed to investigate the correlation between the IL-1 beta-C31T gene polymorphism and susceptibility to breast cancer.