Effect of intrathecal FK506 administration on intraorbital optic nerve crush: an ultrastructural study
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, vol.44, no.4, pp.427-430, 2009 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 44 Issue: 4
- Publication Date: 2009
- Doi Number: 10.3129/i09-071
- Journal Name: CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.427-430
- Keywords: intrathecal administration, FK506, crush injury, optic nerve, protection, RETINAL GANGLION-CELLS, RAT SCIATIC-NERVE, AXONAL REGENERATION, TACROLIMUS FK506, ADULT-RAT, FK-506, UVEITIS, INJURY, STREPTOMYCES, CYCLOSPORINE
- Akdeniz University Affiliated: Yes
Abstract
Objective: Trauma to the optic nerve caused by fractures of the midface and (or) skull base has been simulated by an optic nerve crush injury model. Because the intraorbital segment of the optic nerve is surrounded by subarachnoidal cerebrospinal fluid and dura mater, we aimed to study the influence of intrathecal tacrolimus (FK506) administration after optic nerve crush injury and to determine its role in optic nerve protection or sparing after injury.