Gastroprotective effect of orexin-A and heme oxygenase system
JOURNAL OF SURGICAL RESEARCH, cilt.193, sa.2, ss.626-633, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 193 Sayı: 2
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.jss.2014.08.048
- Dergi Adı: JOURNAL OF SURGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.626-633
- Anahtar Kelimeler: Orexin-A, Ischemia-reperfusion, Gastric, Lesion, Heme oxygenase-1, Heme oxygenase-2, INDUCED GASTRIC DAMAGE, VASCULAR ENDOTHELIAL-CELLS, NITRIC-OXIDE SYNTHASE, ISCHEMIA-REPERFUSION, OXIDATIVE STRESS, RATS, APOPTOSIS, PATHWAY, INJURY, CYTOPROTECTION
- Akdeniz Üniversitesi Adresli: Evet
Özet
Background: Orexin-A, besides playing an important role in the mechanism of food intake, exhibits a potent gastroprotective action against the formation of acute gastric mucosal injury. The aim of the present study was to determine the effect of administered orexin-A against ischemia-reperfusion (I/R)-induced gastric injury on the expression of heme oxygenase (HO)-1 and HO-2 in gastric tissue.