Gastroprotective effect of orexin-A and heme oxygenase system

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Gemici B., Tan R., Birsen I., Izgut-Uysal V. N.

JOURNAL OF SURGICAL RESEARCH, vol.193, no.2, pp.626-633, 2015 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 193 Issue: 2
• Publication Date: 2015
• Doi Number: 10.1016/j.jss.2014.08.048
• Journal Name: JOURNAL OF SURGICAL RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.626-633
• Keywords: Orexin-A, Ischemia-reperfusion, Gastric, Lesion, Heme oxygenase-1, Heme oxygenase-2, INDUCED GASTRIC DAMAGE, VASCULAR ENDOTHELIAL-CELLS, NITRIC-OXIDE SYNTHASE, ISCHEMIA-REPERFUSION, OXIDATIVE STRESS, RATS, APOPTOSIS, PATHWAY, INJURY, CYTOPROTECTION
• Akdeniz University Affiliated: Yes

Abstract

Background: Orexin-A, besides playing an important role in the mechanism of food intake, exhibits a potent gastroprotective action against the formation of acute gastric mucosal injury. The aim of the present study was to determine the effect of administered orexin-A against ischemia-reperfusion (I/R)-induced gastric injury on the expression of heme oxygenase (HO)-1 and HO-2 in gastric tissue.