Gastroprotective effect of orexin-A and heme oxygenase system

Gemici B., Tan R., Birsen I., Izgut-Uysal V. N.

JOURNAL OF SURGICAL RESEARCH, cilt.193, sa.2, ss.626-633, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jss.2014.08.048
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.626-633
  • Anahtar Kelimeler: Orexin-A, Ischemia-reperfusion, Gastric, Lesion, Heme oxygenase-1, Heme oxygenase-2, INDUCED GASTRIC DAMAGE, VASCULAR ENDOTHELIAL-CELLS, NITRIC-OXIDE SYNTHASE, ISCHEMIA-REPERFUSION, OXIDATIVE STRESS, RATS, APOPTOSIS, PATHWAY, INJURY, CYTOPROTECTION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Orexin-A, besides playing an important role in the mechanism of food intake, exhibits a potent gastroprotective action against the formation of acute gastric mucosal injury. The aim of the present study was to determine the effect of administered orexin-A against ischemia-reperfusion (I/R)-induced gastric injury on the expression of heme oxygenase (HO)-1 and HO-2 in gastric tissue.