hMLH1 Gene is not Methylated in Osteosarcoma

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BİLGEN T., KESER İ.

LABMEDICINE, cilt.42, sa.5, ss.280-282, 2011 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1309/lm0orpx97lnvohjh
  • Dergi Adı: LABMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.280-282
  • Anahtar Kelimeler: osteosarcoma, hMLH1, bi-sulfite sequencing, methylation, MICROSATELLITE INSTABILITY, GENOMIC INSTABILITY, CANCER
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Epigenetic silencing of the hMLH1 gene by promoter methylation plays a role in initiation and progression of cancers by leading to increased genomic instability. There is no report on methylation status of the hMLH1 gene in osteosarcoma.