hMLH1 Gene is not Methylated in Osteosarcoma

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BİLGEN T., KESER İ.

LABMEDICINE, vol.42, no.5, pp.280-282, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1309/lm0orpx97lnvohjh
  • Journal Name: LABMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.280-282
  • Keywords: osteosarcoma, hMLH1, bi-sulfite sequencing, methylation, MICROSATELLITE INSTABILITY, GENOMIC INSTABILITY, CANCER
  • Akdeniz University Affiliated: Yes

Abstract

Background: Epigenetic silencing of the hMLH1 gene by promoter methylation plays a role in initiation and progression of cancers by leading to increased genomic instability. There is no report on methylation status of the hMLH1 gene in osteosarcoma.