Clinicopathologic evaluation of CDw75 antigen expression in patients with gastric carcinoma

Elpek G. Ö., GELEN T., KARPUZOGLU G., KARPUZOGLU T., KELES N.

JOURNAL OF PATHOLOGY, cilt.193, sa.2, ss.169-174, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Sayı: 2
  • Basım Tarihi: 2001
  • Dergi Adı: JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-174
  • Anahtar Kelimeler: CDw75 antigen, beta-galactosyl alpha-2,6-sialyltransferase, gastric carcinoma, prognosis, immunohistochemistry, BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE, SIALYLTRANSFERASE, CELLS, TUMOR, CARBOHYDRATE, GLYCOPROTEIN, METASTASIS, MUCOSA, LECTIN, CD75
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Situated on mature B lymphocytes, CDw75 antigen is a sialylated carbohydrate epitope generated by the enzyme beta -galactosyl alpha -2,6-sialyltransferase. Although CDw75 antigen expression was found to be correlated with aggressive behaviour of tumour cells in gastric adenocarcinomas, its prognostic role still remains unknown, The objective of this study was to determine the value of CDw75 antigen expression as a marker of the metastatic potential and prognosis of gastric adenocarcinomas, CDw75 antigen expression was evaluated immunohistochemically in 64 tumours and their nodal metastases, The correlation was analysed between CDw75 antigen expression and selected clinicopathological variables, including surrival.