Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

KARAGÜZEL, ERSAGUN; Kutlu, ÖMER; YULUĞ, ESİN; AYDIN MUNGAN, SEVDEGÜL; KAZAZ, İLKE; Tok, Dogan; Ozgur, Guner

doi:10.1016/j.jpedsurg.2012.01.078

Comparison of the protective effect of dipyridamole and acetylsalicylic acid on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury

KARAGÜZEL E., Kutlu O., YULUĞ E., AYDIN MUNGAN S., KAZAZ İ. O., Tok D. S., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.47, sa.9, ss.1716-1723, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 9
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.jpedsurg.2012.01.078
Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1716-1723
Anahtar Kelimeler: Dipyridamole, Acetylsalicylic acid, Testicular torsion, Rats, Reperfusion injury, CELL-SPECIFIC APOPTOSIS, OXIDATIVE STRESS, SUPEROXIDE ANION, SPERMATIC CORD, VITAMIN-E, TORSION, ASPIRIN, EXPRESSION, BRAIN, PATHOPHYSIOLOGY
Akdeniz Üniversitesi Adresli: Hayır

Özet

Purpose: Ischemia reperfusion injury arising from testicular torsion results in a loss of spermatogenesis and a significant increase in germ cell apoptosis. We investigated the effects of dipyridamole and acetylsalicylic acid (ASA), 2 well-known platelet inhibitors, on testicular ischemia reperfusion injury.