Investigation of AKI with early biomarkers after cardiac surgery

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Mutlu H., GÜNDÜZ E., TİTİZ T., ÖZEN KÜÇÜKÇETİN İ.

Brazilian Journal of Cardiovascular Surgery, cilt.35, sa.5, ss.722-731, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.21470/1678-9741-2019-0178
  • Dergi Adı: Brazilian Journal of Cardiovascular Surgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.722-731
  • Anahtar Kelimeler: Lipocalin-2, CST3 protein, human, Cystatin C, Interleukin-18, Risk Factors, Acute Kidney Injury, Cardiac Surgical Procedures, Biomarkers, Kidney, Postoperative Complications, ACUTE KIDNEY INJURY, ACUTE-RENAL-FAILURE, CYSTATIN C, RISK, PROGRESSION, STRATEGIES, DIALYSIS, THERAPY, BYPASS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

© 2020, Sociedade Brasileira de Cirurgia Cardiovascular. All rights reserved.Objective: To provide a new interpretation of the effect of intraoperative hemodynamic data on postoperative acute kidney injury (AKI) development and to determine the accuracy of some biomarkers which are thought to be the early markers of renal injury. Methods: One hundred adult patients who were connected to the heart-lung pump during open-heart surgery were included in this study. Hemodynamic data, oxygen delivery, and transfusions were recorded intraoperatively, and the preoperative and 3. postoperative hour cystatin C, interleukin-18 (IL-18), and neutrophil gelatinase-associated lipocalin (NGAL) parameters were measured for early detection of kidney damage. In the analysis, 95% significance level was used to determine the difference. Results: According to the Kidney Disease Improving Global Outcomes criterion, AKI developed in 24 patients, 18 of whom were stage 1, two were stage 2, and four were stage 3. AKI (+) patients had more transfusions in the intraoperative period and AKI development was a risk factor for postoperative complications. NGAL and IL-18 levels were found to be approximately two-fold in the postoperative period in AKI (+) patients, whereas cystatin C was not sensitive in AKI detection. Conclusion: AKI development increases the risk of postoperative complications. NGAL and IL-18 were successful in detecting AKI in the early postoperative period.