The association between ischaemia-modified albumin levels in umbilical vein and intrauterine growth restriction

KARADENIZ O., MENDİLCİOĞLU İ. İ., ÖZDEM S. S., Ozekinci M., SANHAL C. Y., Uzun G., ...Daha Fazla

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.35, sa.1, ss.9-12, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/01443615.2014.930101
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-12
  • Anahtar Kelimeler: Asphyxia, diagnosis, intrauterine, IUGR, pH, umbilical cord, CORD BLOOD, BIRTH-WEIGHT, FETAL, BINDING, PREGNANCIES, CHILDREN, MARKER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Intrauterine growth restriction (IUGR) is one of the most common problems in obstetrics. Ischaemia-modified albumin (IMA), a product deriving from albumin as a result of the modification by oxidative free radicals in response to hypoxia, was previously used as a marker of ischaemia in acute coronary syndrome. We performed this study to determine whether umbilical venous IMA levels are associated with IUGR. A total of 40 pregnancies with IUGR were compared with 40 of normal fetal development. Blood samples were obtained from the umbilical vein after delivery. IMA levels in the IUGR group were higher than in the control group (78.74 +/- 6.87 vs 74.43 +/- 7.84 U/ml, respectively, p = 0.011). An elevated IMA level was associated with IUGR (OR: 1.079, 95% CI: 1.000-1.163, p = 0.049). We suggest that IMA, which was formerly proved to arise in ischaemic conditions, may also be a valuable marker in perinatal hypoxia and IUGR detection.