Comparison of Linear Accelerator and Helical Tomotherapy Plans for Glioblastoma Multiforme Patients

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Koca T., Basaran H., Sezen D., Karaca S., Ors Y., Arslan D., ...Daha Fazla

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.15, sa.18, ss.7811-7816, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 18
  • Basım Tarihi: 2014
  • Doi Numarası: 10.7314/apjcp.2014.15.18.7811
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7811-7816
  • Anahtar Kelimeler: Intensity modulated radiation therapy, GMB, dose comparison, linac, helical tomotherapy, INTENSITY-MODULATED RADIOTHERAPY, 3-DIMENSIONAL CONFORMAL RADIOTHERAPY, HIGH-GRADE GLIOMAS, RADIATION-THERAPY IMRT, INTEGRATED BOOST, QUALITY-ASSURANCE, NASAL CAVITY, BRAIN-TUMORS, ARC THERAPY, CANCER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Despite advances in radiotherapy, overall survival of glioblastoma multiforme (GBM) patients is still poor. Moreover dosimetrical analyses with these newer treatment methods are insufficient. The current study is aimed to compare intensity modulated radiation therapy (IMRT) linear accelerator (linac) and helical tomotherapy (HT) treatment plans for patients with prognostic aggressive brain tumors. Material and Methods: A total of 20 GBM patient plans were prospectively evaluated in both linac and HT planning systems. Plans are compared with respect to homogenity index, conformity index and organs at risk (OAR) sparing effects of the treatments. Results: Both treatment plans provided good results that can be applied to GBM patients but it was concluded that if the critical organs with relatively lower dose constraints are closer to the target region, HT for radiotherapeutical application could be preferred. Conclusion: Tomotherapy plans were superior to linear accelerator plans from the aspect of OAR sparing with slightly broader low dose ranges over the healthy tissues. In case a clinic has both of these IMRT systems, employment of HT is recommended based on the observed results and future re-irradiation strategies must be considered.