Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source-detector separation

Canpolat M., Mourant J.

APPLIED OPTICS, cilt.39, sa.34, ss.6508-6514, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 34
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1364/ao.39.006508
  • Dergi Adı: APPLIED OPTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6508-6514
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation; therefore the measurements could be performed through the working channel of an endoscope. (C) 2000 Optical Society of America OCIS codes: 170.3890, 170.5180.