High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas

ŞANLIOĞLU A. D., DIRICE E., ELPEK O., Korcum A. F., BALCI M. K., Omer A., ...Daha Fazla

PANCREAS, cilt.36, sa.4, ss.385-393, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mpa.0b013e318158a4e5
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.385-393
  • Anahtar Kelimeler: TRAIL, death-decoy receptors, pancreas, Langerhans islets, PROSTATE CARCINOMA-CELLS, DIABETES-MELLITUS, FACTOR-ALPHA, FAS LIGAND, BETA-CELLS, NOD MICE, TRAIL, TYPE-1, DESTRUCTION, RECEPTORS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: Type 1 diabetes (T1D) has been characterized by the T cellYmediated destruction of pancreatic beta cells. Although various members of the tumor necrosis factor (TNF) family, such as Fas ligand or TNF, have recently been implicated in the development of T1D, the lack of TNF-related apoptosis-inducing ligand (TRAIL) expression or function facilitates the onset of T1D. Thus, the goal of the present study was to investigate the expression profiles of TRAIL and its receptors in human pancreas.