High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas

ŞANLIOĞLU, AHTER; DIRICE, Ercument; ELPEK, Ozlem; Korcum, AYLİN; BALCI, MUSTAFA; Omer, Abdulkadir; Griffith, Thomas; ŞANLIOĞLU, SALİH

doi:10.1097/mpa.0b013e318158a4e5

High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas

ŞANLIOĞLU A. D., DIRICE E., ELPEK O., Korcum A. F., BALCI M. K., Omer A., ...More

PANCREAS, vol.36, no.4, pp.385-393, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 36 Issue: 4
Publication Date: 2008
Doi Number: 10.1097/mpa.0b013e318158a4e5
Journal Name: PANCREAS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.385-393
Keywords: TRAIL, death-decoy receptors, pancreas, Langerhans islets, PROSTATE CARCINOMA-CELLS, DIABETES-MELLITUS, FACTOR-ALPHA, FAS LIGAND, BETA-CELLS, NOD MICE, TRAIL, TYPE-1, DESTRUCTION, RECEPTORS
Akdeniz University Affiliated: Yes

Abstract

Objectives: Type 1 diabetes (T1D) has been characterized by the T cellYmediated destruction of pancreatic beta cells. Although various members of the tumor necrosis factor (TNF) family, such as Fas ligand or TNF, have recently been implicated in the development of T1D, the lack of TNF-related apoptosis-inducing ligand (TRAIL) expression or function facilitates the onset of T1D. Thus, the goal of the present study was to investigate the expression profiles of TRAIL and its receptors in human pancreas.