Pichia pastoris Promoters

ÖZÇELİK A., Yilmaz S., İNAN M.

RECOMBINANT PROTEIN PRODUCTION IN YEAST, cilt.1923, ss.97-112, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1923
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/978-1-4939-9024-5_3
  • Dergi Adı: RECOMBINANT PROTEIN PRODUCTION IN YEAST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.97-112
  • Anahtar Kelimeler: Methylotrophic yeast, Pichia pastoris, AOX1 promoter, ADH3 promoter, GAP promoter, HETEROLOGOUS PROTEIN-PRODUCTION, STRONG CONSTITUTIVE PROMOTER, YEAST HANSENULA-POLYMORPHA, FED-BATCH CULTIVATION, HIGH-LEVEL SECRETION, METHYLOTROPHIC YEAST, ALCOHOL OXIDASE, GENE-EXPRESSION, AOX1 PROMOTER, CANDIDA-BOIDINII
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The methylotrophic yeast Pichia pastoris (Komagataella phaffii) is used as an expression system for recombinant protein production for a variety of applications. It grows rapidly on inexpensive media containing methanol, glucose, glycerol, or ethanol as a sole carbon source. P. pastoris makes many posttranslational modifications and produces recombinant proteins either intracellularly or extracellularly. Because of these properties, P. pastoris has become a highly preferred host organism for biotechnology, pharmaceutical industry, and researchers.