Purpose To explore the psycho-adaptive changes and the level of psychological growth after childbirth among first-time mothers. Design and Methods This study used a descriptive qualitative approach. Using the purposeful sampling method, 18 primiparous women who received postnatal care between August and September 2017 were interviewed. Findings The women's experiences about psycho-adaptive changes were collected under eight main themes. These themes were change in values, change in personality, change in hand skills and time management, change in priorities, change in problem-solving skills, increase in self-esteem, change in social life, and change in relations, respectively. Practical Implications Nurses should assume important responsibilities, such as childbirth education needs, psycho-adaptive features of the mothering process, culturally-sensitive antenatal visits, and childcare.