Bcl-2 and p53 expression in insular and in well-differentiated thyroid carcinomas with an insular pattern

Pestereli H. E., OGUS M., OREN N., KARPUZOGLU G., KARPUZOGLU T.

ENDOCRINE PATHOLOGY, vol.12, no.3, pp.301-305, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1385/ep:12:3:301
  • Journal Name: ENDOCRINE PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.301-305
  • Keywords: insular thyroid carcinoma, p53, bcl-2, DNA content, ANAPLASTIC CARCINOMA, PAPILLARY, COMPONENT, TUMORS, CELLS
  • Akdeniz University Affiliated: Yes

Abstract

Expression of p53 and bcl-2 oncogenes was investigated in poorly differentiated, so-called insular carcinomas of the thyroid gland and also in the follicular and papillary carcinomas with an insular component. Hematoxylin-eosin sections of 217 thyroid carcinomas were reevaluated for insular carcinoma and also for thyroid carcinomas with an insular component. Immunohistochemical staining method was used for detecting p53 and bcl-2 expression on paraffin blocks of three pure insular, five follicular or papillary thyroid carcinomas with a major insular component (more than 50%) and six with a minor insular component (20-50%). Flow cytometry was also performed in these cases. None of the cases showed p53 immunoreactivity. Bcl-2 expression was observed in all cases and the most intense staining was seen in insular areas. All the cases were diploid. We suggest that bcl-2 plays a role in loss of differentiation of thyroid carcinomas.