Increased bladder apoptosis with alpha-1 adrenoceptor antagonists in benign prostatic hyperplasia

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Erdogru T., Gulkesen K. H., KUKUL E., YALCINKAYA M., KARPUZOGLU G., Baykara M.

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, cilt.36, sa.3, ss.188-193, 2002 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 36 Sayı: 3
• Basım Tarihi: 2002
• Doi Numarası: 10.1080/003655902320131857
• Dergi Adı: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.188-193
• Anahtar Kelimeler: alpha-adrenoceptor antagonists, apoptosis, benign prostatic hyperplasia, bladder, OUTLET OBSTRUCTION, URINARY-BLADDER, OUTFLOW OBSTRUCTION, RAT, ALPHA(1)-ADRENOCEPTORS, DETRUSOR
• Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: To determine whether preoperative usage of alpha-1 adrenoceptor antagonists (alpha-1ARA) prevents the alterations in bladder wall components due to obstruction via changing apoptotic and/or proliferative activity and provides an advantage for improvement of irritative symptoms following removement of bladder outlet obstruction.