Functional deficits and morphological changes in the neurogenic bladder match the severity of spinal cord compression


ÖZSOY Ö., ÖZSOY U., Stein G., Semler O., Skouras E., Schempf G., ...More

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, vol.30, no.5, pp.363-381, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.3233/rnn-2012-110203
  • Journal Name: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.363-381
  • Keywords: Compression spinal cord injury, injury severity, bladder function, BBB rating scale, urinary bladder innervation, LOWER URINARY-TRACT, EXTERNAL URETHRAL SPHINCTER, BOTULINUM-TOXIN-A, PONTINE MICTURITION CENTER, NERVE GROWTH-FACTOR, RAT BLADDER, ULTRASTRUCTURAL EVIDENCE, INTRAVESICAL CAPSAICIN, AUTONOMIC DYSREFLEXIA, PERIAQUEDUCTAL GRAY
  • Akdeniz University Affiliated: Yes

Abstract

Following spinal cord injury (SCI), loss of spinal and supraspinal control results in desynchronisation of detrusor vesicae (parasympathicus) and external urethral sphincter (sympathicus) activity. Despite recovery of lower urinary tract function being a high priority in patients with SCI, effective treatment options are unavailable largely because mechanisms are poorly understood.