Smart antifungal thermosensitive chitosan/carboxymethylcellulose/scleroglucan/montmorillonite nanocomposite hydrogels for onychomycosis treatment

BOZOGLAN B. K., DUMAN O., TUNÇ S.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, cilt.610, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 610
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.colsurfa.2020.125600
  • Dergi Adı: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC
  • Anahtar Kelimeler: Chitosan, Carboxymethylcellulose, Scleroglucan, Montmorillonite, Antifungal hydrogel, Controlled drug release, NAIL LACQUERS, DELIVERY-SYSTEMS, WATER, NANOPARTICLES, FORMULATION, ALGINATE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

In this study, oxiconazole nitrate (OXI)-loaded antifungal thermosensitive chitosan/carboxymethylcellulose/scleroglucan/montmorillonite (CHT/CMC/SGL/MMT) nanocomposite hydrogels were developed for onychomycosis treatment. The presence of 5% (w/w) MMT within hydrogel matrix increased the glass transition temperature of CHT/CMC/SGL material from 63.72 degrees C to 76.75 degrees C and the compressive stress value from 126.45 +/- 8.83 kPa to 266.99 +/- 6.60 kPa. For the use of hydrogel materials in the treatment of onychomycosis, antifungal OXI drug was loaded into the network of thermosensitive CHT/CMC/SGL and CHT/CMC/SGL/MMT hydrogels and the release of OXI from these materials was monitored spectrophotometrically. At the end of 420 min, for hydrogel systems containing 0, 1, 3 and 5 % (w/w) MMT, OXI release amounts were determined as 70.33 +/- 1.74 %, 63.92 +/- 0.31 %, 58.78 +/- 1.45 % and 52.89 +/- 0.21 %, respectively. This means that the drug release depends on the MMT amount within hydrogel matrix and can be controlled by changing the amount of clay mineral in hydrogel material. OXI-loaded new hydrogels showed high antifungal activity against Trichophyton mentagrophytes and Trichophyton rubrum dermatophytes. This study suggests that new antifungal thermosensitive CHT/CMC/SGL/MMT nanocomposite hydrogels could be promising materials for onychomycosis treatment.