The role of AT1 receptor, Ras and NAD(P)H oxidase on p38 MAPK phosphorylation by angiotensin II stimulation in primary cultured vascular smooth muscle cells

Caglar S., Cetin A., Uzuner F., Tokay A., KIRÇA M., YEŞİLKAYA A.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.4, pp.407-416, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5505/tjb.2012.07078
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.407-416
  • Keywords: Vascular smooth muscle cell, Ang II, p38 MAPK, Ras, NADPH oxidase, ACTIVATED PROTEIN-KINASE, PATHWAYS, STRESS, MECHANISMS, EXPRESSION
  • Akdeniz University Affiliated: Yes

Abstract

Aim: Ang II stimulates vascular smooth muscle cells (VSMCs) and activates mitogen protein kinases (MAPKs) in culture media. p38 MAPK, a member of MAPK family, is stimulated by both Ang II and reactive oxygen species. This study was carried out to show Ang II stimulated p38 MAPK activation through Ras and subsequent NADPH oxidase activation in VSMCs.