Beneficial effects of pentoxifylline on cyclosporine-induced nephrotoxicity

Kaputlu I., Sadan G., Karayalcin B., Boz A.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.24, no.5, pp.365-369, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 5
  • Publication Date: 1997
  • Doi Number: 10.1111/j.1440-1681.1997.tb01203.x
  • Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.365-369
  • Keywords: blood pressure, cyclosporine A, nephrotoxicity, pentoxifylline, GLOMERULAR-FILTRATION RATE, MARROW TRANSPLANTATION, RADIOACTIVE AGENTS, AMPHOTERICIN-B, RENAL-FUNCTION, A TREATMENT, FISH-OIL, ENDOTHELIN, DEFORMABILITY, HYPERTENSION
  • Akdeniz University Affiliated: No

Abstract

1. Hypertension and renal failure are the two most common and severe complications due to cyclosporine A (CsA) therapy after transplantation. To determine whether an in vivo treatment with pentoxifylline (PTX) can prevent the toxic effects of CsA, three groups of rats were studied.