Bone Mineral Density and the Relationship between Lipid Profile and Bone Mineral Density in the Rats Administered Juniperus Communis Linn.

USKUN E., Akdogan M., YILDIZ M., Sonmez Y.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, vol.34, no.4, pp.802-806, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2012
  • Journal Name: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.802-806
  • Keywords: Juniperus Communis Linn., Bone Mineral Density, Lipid and lipoproteins, COA REDUCTASE INHIBITORS, RISK, LIPOPROTEIN, FRACTURE, MASS, DIFFERENTIATION, IDENTIFICATION, SIMVASTATIN, ASSOCIATION, DIET
  • Akdeniz University Affiliated: No

Abstract

The aim of the study is to investigate the relationship of Juniperus Communis Lynn. with the bone mineral density in the rats fed with a high cholesterol (1%) diet. Thirty five Wistar albino rats weighed approximately 250-300 were used in this study. The rats are divided in five groups of seven each. Groups I and II were administered 0.5 ml of 0.5% Sodium Carboxy Methyl Cellulose (SCMC), while Groups II, IV and V administered 0.5 ml of juniperus communis linn dissolved in 25, 50, 100 mg/kg. Group I and Group II were fed with normal pellets while the other four groups were fed with pellets containing 1% cholesterol. Levels of lipid profile and High Density Lipoprotein Cholesterol (HDL-C) were defined in all the groups. Furthermore, bone mineral density (B M D) of the animals were obtained with DEXA scanner. BMD values of the rats did not show a different among the groups. Significant negative correlations were determined between BMD measurements and LDL-C levels in all groups connected with dose of Juniperus Communis oil. However, this relationship was not linear.