Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

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Burgucu D., GÜNEY K., Sahinturk D., ÖZBUDAK İ. H., Ozel D., ÖZBİLİM G., ...Daha Fazla

BMC CANCER, cilt.12, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1471-2407-12-481
  • Dergi Adı: BMC CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Tbx3, PTEN, Cancer, Squamous cell carcinoma, GENE, CANCER, TRANSCRIPTION, PROMOTER, PATHWAY, GROWTH, MUTATIONS, PROGRESSION, ASSOCIATION, RESISTANCE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Despite advances in diagnostic and treatment strategies, head and neck squamous cell cancer (HNSCC) constitutes one of the worst cancer types in terms of prognosis. PTEN is one of the tumour suppressors whose expression and/or activity have been found to be reduced in HNSCC, with rather low rates of mutations within the PTEN gene (6-8%). We reasoned that low expression levels of PTEN might be due to a transcriptional repression governed by an oncogene. Tbx2 and Tbx3, both of which are transcriptional repressors, have been found to be amplified or over-expressed in various cancer types. Thus, we hypothesize that Tbx3 may be over expressed in HNSCC and may repress PTEN, thus leading to cancer formation and/or progression.