The PI3K/Akt and MAPK-ERK1/2 pathways are altered in STZ induced diabetic rat placentas

Ozmen A., UNEK G., Kipmen-Korgun D., KORGUN E. T.

HISTOLOGY AND HISTOPATHOLOGY, vol.29, no.6, pp.743-756, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 6
  • Publication Date: 2014
  • Journal Name: HISTOLOGY AND HISTOPATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.743-756
  • Keywords: Placental development, Akt, ERK1/2, Diabetes, Rat, ACTIVATED PROTEIN-KINASE, GROWTH-FACTOR, GENE-EXPRESSION, GLUCOCORTICOID-RECEPTOR, TROPHOBLAST INVASION, INSULIN-RECEPTORS, ENDOTHELIAL-CELL, AKT PATHWAY, DIFFERENTIATION, ERK1/2
  • Akdeniz University Affiliated: Yes

Abstract

Diabetic pregnancy is associated with complications such as early and late embryonic death, fetal growth disorders, placental abnormalities, and embryonal-placental metabolic disorders. Excessive apoptosis and/or changes of proliferation mechanisms are seen as a major event in the pathogenesis of diabetes-induced embryonic death, placental weight and structural anomalies.