Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

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Yildirim M., Demirpence O., KAYA V., Suren D., Karaca M., Evliyaoglu O., ...More

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.15, no.15, pp.6233-6237, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 15
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.15.6233
  • Journal Name: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6233-6237
  • Keywords: Gynecologic cancer, paraoxonase, ceruloplasmin, peritoneal wash cytology, SERUM PARAOXONASE, ARYLESTERASE ACTIVITIES, TURKISH POPULATION, OVARIAN-CANCER, BREAST-CANCER, LUNG-CANCER, 1 PON1, CYTOLOGY, POLYMORPHISMS, ATHEROSCLEROSIS
  • Akdeniz University Affiliated: Yes

Abstract

Background: Intraperitoneal spread of gynecologic cancers is a major cause of mortality and morbidity and often presents with malignant ascites. Microscopic tumor spread can be demonstrated by a peritoneal wash cytology and help assess the prognosis of the disease. In our study, the roles of paraoxonase and ceruloplasmin, measured in peritoneal washing fluid of patients operated for gynecologic pathologies in differential diagnosis was investigated. Materials and Methods: Patients operated for malign or benign gynecologic pathologies in Antalya Education and Research Hospital Gynecology Clinic between 2010-2012 were included in the study. Samples were obtained during surgery. Results: A statistically significant difference was detected between patients with benign and malign diseases with regards to PON1 levels measured in peritoneal washing fluid (p:0.044), the average values being 64.2 +/- 30.8 (Range 10.8-187.2) and 41.4 +/- 21.4 (Range 10.4-95.5), respectively. No significant variation was evident for ceruloplasmin. Conclusions: Paraoxonase levels measured in peritoneal washing fluid may contribute to the differentiation of malign-benign diseases in gynecologic pathologies.