Calcium release near L-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol.89, pp.326-334, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 89
- Publication Date: 2015
- Doi Number: 10.1016/j.yjmcc.2015.10.008
- Journal Name: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.326-334
- Keywords: Action potential, Repolarization variability, Remodeling, Proarrhythmia, Calcium handling, TORSADES-DE-POINTES, SHORT-TERM VARIABILITY, CA2+ RELEASE, REPOLARIZATION VARIABILITY, EARLY AFTERDEPOLARIZATIONS, ATRIOVENTRICULAR-BLOCK, NA+/CA2+ EXCHANGER, CARDIAC MYOCYTES, DOWN-REGULATION, CANINE MODEL
- Open Archive Collection: AVESIS Open Access Collection
- Akdeniz University Affiliated: Yes
Abstract
Beat-to-beat variability of ventricular repolarization (BVR) has been proposed as a strong predictor of Torsades de Pointes (TdP). BVR is also observed at the myocyte level, and a number of studies have shown the importance of calcium handling in influencing this parameter. The chronic AV block (CAVB) dog is a model of TdP arrhythmia in cardiac hypertrophy, and myocytes from these animals show extensive remodeling, including of Ca2+ handling. This remodeling process also leads to increased BVR We aimed to determine the role that (local) Ca2+ handling plays in BVR.