Calcium release near L-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog

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Antoons G., JOHNSON D. M., DRIES E., SANTIAGO D. J., Ozdemir S., Lenaerts I., ...More

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol.89, pp.326-334, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89
  • Publication Date: 2015
  • Doi Number: 10.1016/j.yjmcc.2015.10.008
  • Journal Name: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.326-334
  • Keywords: Action potential, Repolarization variability, Remodeling, Proarrhythmia, Calcium handling, TORSADES-DE-POINTES, SHORT-TERM VARIABILITY, CA2+ RELEASE, REPOLARIZATION VARIABILITY, EARLY AFTERDEPOLARIZATIONS, ATRIOVENTRICULAR-BLOCK, NA+/CA2+ EXCHANGER, CARDIAC MYOCYTES, DOWN-REGULATION, CANINE MODEL
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Beat-to-beat variability of ventricular repolarization (BVR) has been proposed as a strong predictor of Torsades de Pointes (TdP). BVR is also observed at the myocyte level, and a number of studies have shown the importance of calcium handling in influencing this parameter. The chronic AV block (CAVB) dog is a model of TdP arrhythmia in cardiac hypertrophy, and myocytes from these animals show extensive remodeling, including of Ca2+ handling. This remodeling process also leads to increased BVR We aimed to determine the role that (local) Ca2+ handling plays in BVR.