Protective effects of amifostine on ischemia-reperfusion injury of rat kidneys

MERTER A. A., Mayır B., Erdogan O., Colak T.

INDIAN JOURNAL OF PHARMACOLOGY, cilt.47, sa.2, ss.185-189, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0253-7613.153427
  • Dergi Adı: INDIAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.185-189
  • Anahtar Kelimeler: Amifostine, ischemia-reperfusion injury, kidney, ISCHEMIA/REPERFUSION INJURY, OXYGEN, PREVENTION, POTENCY, HEART, MODEL
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist.