Protective effects of amifostine on ischemia-reperfusion injury of rat kidneys
INDIAN JOURNAL OF PHARMACOLOGY, vol.47, no.2, pp.185-189, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 47 Issue: 2
- Publication Date: 2015
- Doi Number: 10.4103/0253-7613.153427
- Journal Name: INDIAN JOURNAL OF PHARMACOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.185-189
- Keywords: Amifostine, ischemia-reperfusion injury, kidney, ISCHEMIA/REPERFUSION INJURY, OXYGEN, PREVENTION, POTENCY, HEART, MODEL
- Akdeniz University Affiliated: Yes
Abstract
Objectives: Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist.