Advanced oxidation protein products and ischaemia-modified albumin in obstructive sleep apnea

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OZBEN S., Huseyinoglu N., Hanikoglu F., Guvenc T. S., Yildirim B. Z., Cort A., ...More

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.44, no.11, pp.1045-1052, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1111/eci.12338
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1045-1052
  • Keywords: Advanced oxidation protein products, ischaemia-modified albumin, obstructive sleep apnea, oxidative stress, total antioxidative capacity, total oxidative status, LIPID-PEROXIDATION, DNA-DAMAGE, STRESS, HEMODIALYSIS, MARKER, ANTIOXIDANTS, DYSFUNCTION, DIAGNOSIS, HYPOXIA, OBESITY
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

BackgroundSeveral studies have shown that obstructive sleep apnea increases incidence of cardiovascular morbidity and mortality. The high systemic oxidative stress in obstructive sleep apnea has been considered as a major pathogenic mechanism leading to cardiovascular disease. Oxidative stress-related lipid and DNA oxidation in obstructive sleep apnea have been reported in the previous studies. In contrast, there is limited and contradictory information regarding protein oxidation in obstructive sleep apnea patients such as ischaemia-modified albumin and advanced oxidation protein products. Therefore, we aimed to investigate plasma ischaemia-modified albumin and advanced oxidation protein products and their correlation with total oxidative status and total antioxidative capacity in the obstructive sleep apnea patients.