Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.12, pp.1770-1777, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 12
- Publication Date: 2014
- Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1770-1777
- Keywords: Medulla spinalis, Spinal trauma, Methylprednisolone, Montelukast, Superoxide dismutase, Malondialdehyde, TRAUMATIC BRAIN-INJURY, CYSTEINYL LEUKOTRIENE RECEPTOR-1, SUPEROXIDE-DISMUTASE, CEREBROSPINAL-FLUID, BB ISOENZYME, EXPRESSION, DAMAGE, SERUM, ASSAY, CSF
- Akdeniz University Affiliated: Yes
Abstract
OBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI).