Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats

CAVUS G., Altas M., Aras M., Ozgur T., Serarslan Y., Yilmaz N., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, sa.12, ss.1770-1777, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2014
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1770-1777
  • Anahtar Kelimeler: Medulla spinalis, Spinal trauma, Methylprednisolone, Montelukast, Superoxide dismutase, Malondialdehyde, TRAUMATIC BRAIN-INJURY, CYSTEINYL LEUKOTRIENE RECEPTOR-1, SUPEROXIDE-DISMUTASE, CEREBROSPINAL-FLUID, BB ISOENZYME, EXPRESSION, DAMAGE, SERUM, ASSAY, CSF
  • Akdeniz Üniversitesi Adresli: Evet

Özet

OBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI).