Akademik Veri Yönetim Sistemi
1st European Congress of Laboratory Medicine / Medical Biopathology, Athens, Yunanistan, 26 - 30 Mart 2025, ss.15, (Özet Bildiri)
Ikbal Ozen Kucukcetin1, Muhammed Emin
Ceylan1, Ceyda Seren Bedel1, Ferah Kizilay2,
Nurullah Ozsari1, Berke Ozturk1,
Halide Akbas1, Sebahat Ozdem1
1Akdeniz
University Faculty of Medicine Department of Medical
Biochemistry
2Akdeniz
University Faculty of Medicine Department of Neurology
CRP/ALBUMİN
AND INFLAMMATORY INDEX PARAMETERS IN INDIVIDUALS WITH OLIGOCLONAL BAND POSITIVITY
IN CSF AND DIAGNOSED WITH MULTIPLE SCLEROSIS
Introduction: Multiple
sclerosis (MS) is a chronic demyelinating Disease of the central nervous system
that progresses with attacks and remissions caused by genetic and environmental
factors. Low-grade systemic inflammation is suggested to contributed to
pathogenesis. It is important to recognize MS at an early stage as it causes
disability and cognitive impairment. Therefore, for a rapid and accurate
diagnosis, it is necessary to evaluate the role of easily accessibl,
non-invasive parameters in clinical laboratories in the diagnosis of MS.
Objective: In
this study, we aimed to evaluate the performance of CRP/albumin ratio, RDW and
MPV, and inflammatory indices obtained from hemogram results in the diagnosis
of MS.
Materials and Methods: Our
study included 164 patients who were diagnosed with MS 134 healthy subject as
control group. Absolute neutrophil, lymphocyte and platelet counts and
CRP/albumin, neutrophil/lymphocyte (NLR), platelet/lymphocyte (TLR), systemic
immune-inflammatory (SII) and systemic inflammatory response (SIRI) indices of
the patient group at the time of diagnosis were evaluated.
Hemogram was performed using
the Sysmex XN-1000,CRP and albumin tests were performed using the Roche
cobas-8000 autoanalyzer.
Statistical analysis were
performed using GraphPad Prism 5. The Student's t-test compared group means,
Pearson correlation assessed variable relationships, and ROC analysis evaluated
parameters for MS diagnosis. Significance was set at p < 0.05
Results and Conclusions: The
levels of CRP (p=0.02), neutrophil (p<0.0001), MPV p=0.04) in the MS group,
NLR (p<0.0001), TLR (p=0.0004), SII (p<0.0001), SIRI ( p<0,0001 ) and
CRP/albumin (p=0.015) ratios were significantly higher than the control group,
while albumin levels p<0.0001) were
significantly lower. In the ROC analysis performed for all parameters, the area
under the curve was found to be the highest for NLR (AUC: 0.7340, 95% CI:
0.6788-0.7891, p<0.0001).
It is thought that the
neutrophil/lymphocyte ratio can be used as a useful biomarker in the diagnosis
of MS.