A macrophage activation marker chitotriosidase in women with PCOS: does low-grade chronic inflammation in PCOS relate to PCOS itself or obesity?

Alanbay I., Ercan C. M., SAKINCI M., Coksuer H., Ozturk M., Tapan S.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.286, no.4, pp.1065-1071, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 286 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1007/s00404-012-2425-0
  • Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1065-1071
  • Keywords: Chitotriosidase, Inflammation, Macrophage, PCOS, POLYCYSTIC-OVARY-SYNDROME, INSULIN-RESISTANCE, ADIPOSE-TISSUE, FAT DISTRIBUTION, ADIPOCYTE DEATH, EXPRESSION, GLUCOSE, EXCESS
  • Akdeniz University Affiliated: Yes

Abstract

Polycystic ovary syndrome (PCOS) is described as a low-grade chronic inflammatory state where the macrophage infiltration increased in visceral fat play the major role. The aim of this study was to assess chitotriosidase (ChT) activity (an activated macrophage marker) in women with PCOS and controls and to evaluate its correlation with anthropometric and biochemical parameters.