Comparison of Cystatin C and beta-Trace Protein Versus Tc-99m-DTPA Plasma Sampling in Determining Glomerular Filtration Rate in Chronic Renal Disease


Creative Commons License

AYDIN F., Budak E., Demirelli S., Oner A. O., Korkma S., SÜLEYMANLAR G., ...Daha Fazla

JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY, cilt.43, sa.3, ss.206-213, 2015 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2967/jnmt.115.154799
  • Dergi Adı: JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.206-213
  • Anahtar Kelimeler: glomerular filtration rate, cystatin C, beta trace protein, SERUM CONCENTRATION, MARKER, BETA-2-MICROGLOBULIN, GFR, TRANSPLANTATION, EQUATIONS, FORMULA, DTPA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Glomerular filtration rate (GFR) is the best indicator of renal function. The gold standard for GFR measurement is inulin clearance. However, its measurement is inconvenient, time-consuming, and costly. Thus, in both scientific studies and routine clinical practice nuclear medicine methods (Tc-99m-diethylenetriaminepentaacetic acid [Tc-99m-DTPA] and (51) Cr-ethylenediaminetetraacetic acid [Cr-51-EDTA]) are preferred, and they correlate strongly with inulin clearance. In addition, cystatin C and (beta-trace protein have also recently been used for this purpose. In the literature, however, data are limited about the clinical value of cystatin C and (beta-trace protein in GFR measurement in chronic renal disease (CRD), and the results have been inconclusive. In this study, we aimed to determine the efficiency of cystatin C and (beta-trace protein in the determination of GFR in CRD patients. Methods: Eighty-four patients with CRD were included in the study (59 men and 25 women; age range, 21-88 y; mean age, 61 y). GFR was calculated using the goldstandard Tc-99m-DTPA 2-sample plasma sampling method (TPSM) and 2 alternative methods: a formula using cystatin C and a formula using (beta-trace protein. The correlation between TPSM and the cystatin C and (beta-trace protein methods was assessed, and Bland-Altman analysis was used to graph scatterplots of the differences at a confidence interval of 95% (mean difference +/- 1.96 SDs). Results: GFRs calculated using both alternative methods correlated strongly with those calculated using the gold standard. However, the correlation was stronger for the cystatin C method than for the (beta-trace protein method, and neither method produced reliably consistent GFRs. Conclusion: This study demonstrated that cystatin C and (beta-trace protein do not reflect GFR with sufficient accuracy.