Possible use of a novel portable desalination system was investigated experimentally. The system is based on humidification-dehumidification principle add thermoelectric cooling technique. A thermoelectric cooler was integrated into the system to enhance the process of both humidification and dehumidification. A prototype was fabricated and its performance was tested for various working conditions of the prototype to observe complex relation between psychrometric and thermoelectric phenomena. The effect of feed water mass flow rate and air flow velocity on the COP value of the thermoelectric cooler and clean water production of the system were examined. The maximum daily yield of the system and the COP value of the thermoelectric cooler unit were recorded as 143.6 g and 0.78, respectively. (c) 2014 Elsevier Ltd. All rights reserved.