p27 labeling index and proliferation in gastrointestinal stromal tumors: Correlations with clinicopathologic factors and recurrence

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GELEN T., Elpek G. Ö., AKSOY N., OGUS M., KELES N.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, vol.33, no.7, pp.346-352, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2003
  • Doi Number: 10.1093/jjco/hyg071
  • Journal Name: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.346-352
  • Keywords: p27, proliferation, Ki-67, gastrointestinal stromal tumors, recurrence, DEPENDENT KINASE INHIBITOR, GROWTH-FACTOR RECEPTOR, PROGNOSTIC-SIGNIFICANCE, CLINICAL-SIGNIFICANCE, P27(KIP1) EXPRESSION, G1-S MODULATORS, CDK INHIBITORS, DNA-PLOIDY, CYCLIN-D, CELL
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Background: Low expression of p27, a cyclin-dependent kinase inhibitor, has recently been reported to be associated with poor prognosis of many tumors. Moreover, an inverse relationship between p27 expression and proliferation was also noted. Although accumulating data indicate a correlation between high proliferation rate and aggressive behavior of gastrointestinal stromal tumors, no conclusive correlation between p27 expression and either tumor recurrence or proliferation has been established yet in this disease. The aim of this study was to immunohistochemically investigate the association of p27 expression (as measured by the p27 labeling index: p27L1) with recurrence and proliferation (as measured by the Ki-67 labeling index: KLI) in gastrointestinal stromal tumors.