ANTIGENOTOXIC PROPERTIES OF CHLOROPHYLLIN AND CHLOROPHYLLS IN THE DROSOPHILA WING SPOT TEST

Demir E., Kocaoglu S., KAYA B.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.19, sa.12B, ss.3131-3138, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 12B
  • Basım Tarihi: 2010
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3131-3138
  • Anahtar Kelimeler: Drosophila melanogaster, chlorophyllin, chlorophyll a, chlorophyll b, cobalt chloride, potassium dichromate, DNA-DAMAGE, VITAMIN-C, IN-VIVO, SOMATIC MUTATION, EPIDEMIOLOGIC EVIDENCE, CANCER PREVENTION, COBALT COMPOUNDS, V79 CELLS, GENOTOXICITY, RECOMBINATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

In this study, the protective effects of chlorophyllin, chlorophyll a and chlorophyll b in response to both potassium dichromate (K2Cr2O7) and cobalt chloride (CoCl2) were investigated using the Drosophila wing somatic mutation and recombination test in vivo. For this purpose, two groups were formed for tested chemicals, with a pre-treatment and a co-treatment for the antimutagenic group. When the results were compared with those of individuals exposed only to genotoxic metal doses, chlorophyllin, chlorophyll a and chlorophyll b clearly decreased genotoxic activity of CoCl2 in both treatments. However, it seems that decrease in inhibition rate does not depend on the dose. The genotoxic activity of K2Cr2O7 increased in the treatments with chlorophyll a and b, being higher in the 48 +/- 4 h pretreatment, while the genotoxic activity of K2Cr2O7 with chlorophyllin increased in the co-treatment.