Continuous Erythropoietin Receptor Activator Ameliorates Diabetic Kidney Disease in Rats

Gunal M. Y., Eren Z., Bakir E. A.

TURKISH JOURNAL OF NEPHROLOGY, vol.29, no.4, pp.264-272, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.5152/turkjnephrol.2020.3958
  • Journal Name: TURKISH JOURNAL OF NEPHROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.264-272
  • Keywords: Continuous erythropoietin receptor activator, diabetic kidney disease, inflammation, oxidative stress, experimental model, renin-angiotensin system, OXIDATIVE STRESS, EPOETIN BETA, NEPHROPATHY, PATHWAYS, ISCHEMIA, MODEL, CERA
  • Akdeniz University Affiliated: Yes

Abstract

Objective: Diabetic kidney disease (DKD) is still a significant cause of morbidity in patients with diabetes. In this study, we examined the potential effects of continuous erythropoietin receptor activator (CERA) on oxidative stress, inflammation, and the renin-angiotensin system in a rat model of DKD induced by streptozocin.