The use of amniotic membrane in flexor tendon repair: an experimental model

Demirkan F., Colakoglu N., Herek O., Erkula G.

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, vol.122, no.7, pp.396-399, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 122 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1007/s00402-002-0418-3
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.396-399
  • Keywords: flexor tendon, repair, reconstruction, adhesion, amniotic membrane
  • Akdeniz University Affiliated: No


Background: The objective of this study was to investigate the use of amniotic membrane as a long-term bioprosthesis in hand surgery. The role of the amniotic membrane was investigated in chickens with regard to the prevention of adhesion formation following tendon repair in zone II. Methods: In the control group, the flexor tendon sheath was excised and the tendon repaired. In group II, both the flexor digitorum profundus tendon and its sheath were repaired. In group III, the repaired tendon was covered with amniotic membrane. Histological evaluation of the repaired tendons were done at 3, 6 and 12 weeks. Results: Results of histologic examination demonstrated that use of the amniotic membrane significantly reduced the amount of adhesion compared with the other groups. Three months after implantation no remnants of amniotic membrane could be identified at the tendon repair site. Conclusions: Amniotic membrane is easily prepared, and because of its cost effectiveness, its use in the prevention and treatment of adhesions should always be kept in mind.